Promising Immunosuppressive Results Through Liposomal Clodronate

By Teri Farley


Everyday scientists and medical doctors work together to discover possible treatments, more likely a better one, for various medical diseases. Up until now, several medical conditions remain incurable such as AIDS and Cancer. But with continuous medical study and experimentation, some experiments have shown promising results, for an instance in autoimmune diseases such as that with liposomal clodronate.

True enough, the results on the several studies for such therapy were very promising, offering a new hope for patient suffering from immune system abnormalities. Liposome clodronate differs from any kind of therapy as it is delivered intracellularly. With the use of several advancements in medical therapy, treatment of medical diseases have become quite sophisticated indeed.

The immune system has an important role in a man's health. Under normal circumstances, the immune system defends the body from foreign cells which may cause infection such as common cough and colds. In addition to that, it may also send off several defensive mechanisms in the body perhaps to prevent additional trauma.

In other words, under normal circumstances the immune system is helpful. However, for some reason the immune system may not be functioning how it's supposed to be. In fact, it may cause diseases in the body thus the term, autoimmune disease meaning, "self'' made disease. Your own immune system is fighting with your own healthy cells and without medical intervention disease will progress rather quickly.

Clodronic acid liposome therapy, targets the macrophages to efficiently halt the attack of healthy cells. Suppressing your macrophages will slow down inflammation thus decreasing the pace of disease progression. Some autoimmune diseases have life threatening effect when not intervened properly, for an instance in myasthenia gravis.

Autoimmune diseases are medical conditions caused by the immune system itself. Macrophages, the core cell of the immune system, attack healthy cells causing inflammation such as those in multiple sclerosis, pernicious anemia, rheumatoid arthritis and so on. During transplant, macrophages may also attack the new cells coming from the graft causing the body to reject it.

Using the liposomes as a drug vehicle, clodronic acid will be delivered into your phagocytic cell, or macrophages damaging it irreversibly then kills it eventually through apoptosis. Aptly name as the macrophage "suicide'', this will result to a decreased or minimal immune reaction hence patients with autoimmune disease may show improvement from their condition.

Additionally, transplant rejection will be prevented perhaps improving the patient's quality of life. With cancer, clodronic acid showed promising results in improving the action of anti tumor drugs by increasing its level of plasma absorption. Cancer is a strong disease to fight and it needs the patient to be very responsive to his treatment to achieve good results. Clodronic acid does not cure cancer but rather, pose as a good conjunctive therapy for anti tumor or antineoplastic drugs.

The liposomal clodronate is no doubt a wonder drug as far as autoimmune diseases and transplantation is concerned. Medical studies and experiments are still going on for the therapeutic effect of such therapy in anti neoplastic drugs or Cancer in particular.




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