The Relevance Of Clodronate Liposome In Medical Science

By Roxanne Cruz


Medical science, being one of the most fascinating field in the industry has found different solutions to different problems over time. Before, yellow fever for example killed thousands of residents in different areas. But because of the discoveries of the assiduous medical scientists, yellow fever vaccine was invented. Clodronate liposome is one of those outstanding discoveries that will play a great role in the field of medicine.

Clodronate disodium or clodronic acid, or known commonly as clodronate is the first generation of bisphosphonate without nitrogen. It is a medicine and is approved to be used for the prevention and treatment of osteoporosis cases to women who are at their post menopausal stage. It is also said to deplete macrophages.

These are white blood cells within tissues. Macrophages are produced by the division of the white blood cells formed in the bone marrow and spleen. These kind of white blood cell is known to be as monocytes which ingest foreign particles after it was formed. Basically, macrophage is the core of the system which fight against infectious viruses and diseases.

Liposomes, in cell biology, are the microscopic sac that are composed of fatty liquids. They are used in the experimental research of the cell. It can be supplied with drugs used in curing cancer and other diseases. It usually contained of liquid solutions and composed of phospholipids.

Clodronate liposome is a discovery which functions to suppress the macrophage. It is true that immune system fights bacteria and viruses. Through various steps so called the immune response, the system attacks these infectious invaders that may cause disease. But at the same time, this system could also be a culprit in the human body.

In natural circumstances, the healthy immune system will cope diseases up like coughs and colds. In the contrary, the damaged system will attack every cells it will eat each particles, both the healthy and damaged. When this doom happens, severe illnesses will take place affecting the body from functioning well.

As mentioned earlier, immune response protects the body from viral invasion. However, several damages will lead to grave autoimmune medical conditions caused by transplant rejection. This transplant rejection is one of the effects of the response. As a new organ in places on the transplant patient, cells will incite the system to attack the organ cells that will lead to rejection.

Medical people discovered a certain drug that will treat and cure cases like those. This is made of bisphosphonate the will lessen macrophage. It will be transplanted to the organ cell and as soon as it detected that it is foreign, it will automatically cover the whole transplant up and try to eat them through the so called phagocytosis.

Clodronate liposome also helps to improve anti tumor effects caused by anti tumor drugs during cancer. This may not be able to cure the disease but somehow it will increase plasma absorption. Though this discovery is of great significance in the medical science, before actually resorting in taking it, consult you doctor first.




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